Kumiko Isse Selected Research

Cornified Envelope Proline-Rich Proteins

3/2014	Small proline rich protein 2a in benign and malignant liver disease.
10/2013	SPRR2A expression in cholangiocarcinoma increases local tumor invasiveness but prevents metastasis.

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Kumiko Isse Research Topics

Disease

11	Neoplasms (Cancer) 01/2022 - 02/2004
7	Cholangiocarcinoma 08/2015 - 11/2003
4	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2022 - 01/2017
4	Reperfusion Injury 06/2015 - 07/2011
4	Necrosis 03/2015 - 06/2007
3	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 08/2006 - 03/2005
2	Ischemia 06/2015 - 07/2011
2	Liver Diseases (Liver Disease) 03/2014 - 11/2010
2	Wounds and Injuries (Trauma) 06/2012 - 03/2010
2	Inflammation (Inflammations) 09/2009 - 06/2005
2	Biliary Atresia 04/2009 - 10/2007
2	Infections 04/2009 - 10/2007
2	Cysts 10/2006 - 02/2004
1	Merkel Cell Carcinoma 01/2020
1	Adenocarcinoma 01/2019
1	Urinary Bladder Neoplasms (Bladder Cancer) 01/2019
1	Glioblastoma (Glioblastoma Multiforme) 01/2019
1	Glioma (Gliomas) 01/2019
1	Prostatic Neoplasms (Prostate Cancer) 01/2019
1	Neuroendocrine Carcinoma 01/2017
1	Breast Neoplasms (Breast Cancer) 08/2015
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 07/2014
1	Body Weight (Weight, Body) 09/2009
1	Carcinogenesis 09/2009
1	Melanoma (Melanoma, Malignant) 10/2007
1	Choledochal Cyst (Choledochal Cysts) 10/2007
1	Xanthogranulomatous cholecystitis 10/2007
1	Liver Cirrhosis (Hepatic Cirrhosis) 10/2006
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 10/2006
1	Autoimmune Diseases (Autoimmune Disease) 08/2006
1	Neoplasm Metastasis (Metastasis) 04/2006
1	Carcinoma (Carcinomatosis) 04/2006
1	Cholangitis 06/2005

Drug/Important Bio-Agent (IBA)

6	Proteins (Proteins, Gene)FDA Link 01/2019 - 03/2005
6	LigandsIBA 01/2019 - 06/2005
5	rovalpituzumab tesirineIBA 01/2020 - 01/2017
4	Immunoconjugates (Immunoconjugate)IBA 01/2022 - 01/2018
3	delta proteinIBA 01/2020 - 01/2018
3	CytokinesIBA 08/2006 - 03/2005
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2017
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2014 - 04/2006
2	Cornified Envelope Proline-Rich ProteinsIBA 03/2014 - 10/2013
2	Estrogens (Estrogen)FDA Link 03/2010 - 02/2004
2	Messenger RNA (mRNA)IBA 03/2010 - 03/2005
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 09/2009 - 01/2008
2	Double-Stranded RNA (RNA, Double Stranded)IBA 04/2009 - 10/2007
2	NF-kappa B (NF-kB)IBA 05/2008 - 10/2007
2	Toll-Like Receptors (Toll-Like Receptor)IBA 10/2007 - 11/2003
2	LipopolysaccharidesIBA 06/2007 - 03/2005
1	Pharmaceutical PreparationsIBA 01/2022
1	CalicheamicinsIBA 01/2022
1	AntigensIBA 01/2019
1	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 01/2019
1	RNA (Ribonucleic Acid)IBA 01/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2017
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 08/2015
1	tyrosine receptor (receptor, tyrosine)IBA 08/2015
1	Phosphotransferases (Kinase)IBA 08/2015
1	Adenosine Triphosphate (ATP)IBA 03/2015
1	Surface-Active Agents (Surfactants)IBA 08/2014
1	Small Interfering RNA (siRNA)IBA 10/2013
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2013
1	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2012
1	ElementsIBA 01/2012
1	Alanine Transaminase (SGPT)IBA 07/2011
1	Hematoxylin (Haematoxylon)IBA 11/2010
1	Eosine Yellowish-(YS) (Eosin)IBA 11/2010
1	Interleukin-6 (Interleukin 6)IBA 03/2010
1	Estrogen Receptor betaIBA 03/2010
1	Estrogen Receptor alphaIBA 03/2010
1	AntibodiesIBA 03/2010
1	ProstaglandinsIBA 09/2009
1	CaspasesIBA 09/2009
1	Transaminases (Aminotransferases)IBA 09/2009
1	Staphylococcal Protein A (Protein A)IBA 05/2008
1	Docosahexaenoic AcidsIBA 01/2008
1	Arachidonic Acid (Vitamin F)IBA 01/2008
1	beta CateninIBA 01/2008
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2008
1	Eicosapentaenoic AcidIBA 01/2008
1	15-hydroxyprostaglandin dehydrogenaseIBA 01/2008
1	Dinoprostone (PGE2)FDA Link 01/2008
1	Protein Kinases (Protein Kinase)IBA 10/2007
1	Single-Stranded DNA (DNA, Single Stranded)IBA 10/2007
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 10/2007
1	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA 10/2007
1	Scavenger Receptors (Scavenger Receptor)IBA 10/2007
1	Interleukin-8 (Interleukin 8)IBA 06/2007
1	Tyrosine Kinase InhibitorsIBA 10/2006
1	ErbB Receptors (EGF Receptor)IBA 10/2006
1	Gefitinib (Iressa)FDA Link 10/2006
1	Peptides (Polypeptides)IBA 08/2006
1	AutoantigensIBA 08/2006
1	PPAR gammaIBA 06/2005

Therapy/Procedure

3	Therapeutics 01/2019 - 04/2006
3	Liver Transplantation 06/2015 - 07/2011
1	Castration 01/2019
1	Immunotherapy 07/2014
1	Transplantation 01/2013
1	Chemoprevention 01/2008